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| | Title: | What is Cirrhosis? | | Article: | Chronic inflammation of the liver in individuals with
chronic hepatitis leads to the scarring (called
fibrosis) of the liver. Fibrosis occurs when scar
tissue is formed faster than it can be broken down.
Viruses, chronic alcohol abuse, blockage of bile
outflow and several other reasons cause this
inflammation. Among viruses the leading cause is the
hepatitis C virus. The infection of people with
hepatitis B viruses decreased recently due to
vaccinations.
Liver fibrosis progresses and eventually leads to
cirrhosis of the liver which impairs the liver to
function. Cirrhosis (extensive liver scarring) is the
long-term (10–40 years) result of liver scarring and
fibrosis. Currently, there are no approved therapies
to treat liver fibrosis.
Your doctor checks the amount of fibrosis in your
liver. Then, he can predict how your disease will
progress and find the most appropriate way to deal
with your disease. To grade the condition doctors take
biopsy (a small liver sample that they get by a hollow
needle).
The degree of liver fibrosis is graded according to
Knodell, Metavir or Ishak grading scales.
Treatment of liver fibrosis.
Treatment of liver fibrosis is experimental.
Some research in animals shows that investigational
drug may suppress the processes of liver scarring
(fibrosis). Other studies with drugs similar to some
anti-diabetic drugs in people with liver fibrosis find
that liver inflammation and fibrosis can be
suppressed.
Treatment for Hepatitis C virus may stop or even
reverse damage in liver fibrosis.
Obviously, avoiding alcohol is very beneficial for you
liver.
Surgical treatment involves different types of
shunting (sort of detour) of blood from guts around
the liver. This does not help with removal of toxic
substances, which are cleaned by a normal liver.
However it prevents rupture of some blood vessels that
are usually overfilled with blood in the late stages
of cirrhosis. Thus it prevents possible deadly,
unstoppable bleeding if those vessels are ruptured.
Another surgical possibility is a transplantation of a
donor’s liver. | | Author: | Aleksandr Kavokin, MD, PhD | | System: | Liver | | Subject: | Cirrhosis | | Abstract: | Cirrhosis (extensive liver scarring) is the
long-term (10–40 years) result of liver scarring and
fibrosis. | | Website: | www.kavokin.com | | Time: | 18:00 | | Reference: | | | Reference 2: | |
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©2006 Kavokin.com
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Articles by Aleksandr Kavokin, MD, PhD
Doctor-Robot (Free section)